L-Serine
Description:
Product Name: L-Serine
Molecular Formula： C3H7NO3
Molecular Weight： 105.09
CAS No： 56-45-1
L-Serine, also known as beta-hydroxyalanine, is a non-essential amino acid that plays a role in the metabolism of fats and fatty acids and the growth of muscles because it helps in the production of immune hemoglobin and antibodies and maintains a healthy immune system. Serine is also required.
L-Serine plays a role in the production and processing of cell membranes, the synthesis of muscle tissue and sheaths surrounding nerve cells.
Specifications:
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L-Serine
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USP36
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AJI92
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CP2015 ( Injection Grade )
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EP8
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Assay
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98.5-101.5%
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99.0-101.0%
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≥98.5%
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98.5-101.0%
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PH
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/
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5.2-6.2
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5.5-6.5
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/
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Specific rotation[a]D20
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/
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+14.4°-+15.5°
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+14.0°-+15.6°
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+14.0°-+16.0°
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Specific rotation[a]D25
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+14.0°-+15.6°
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/
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/
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Transmittance(T430)
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/
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≥98.0%
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≥98.0%
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clear & colorless ≤BY6
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Chloride(Cl)
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≤0.05%
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≤0.02%
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≤0.02%
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≤0.02%
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Ammonium(NH4)
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/
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≤0.02%
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≤0.02%
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≤0.02%
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Sulfate(SO4)
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≤0.03%
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≤0.02%
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≤0.02%
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≤0.03%
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Iron(Fe)
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≤30PPM
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≤10PPM
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≤10PPM
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≤10PPM
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Heavy metals(Pb)
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≤15PPM
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≤10PPM
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≤10PPM
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≤10PPM
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Arsenic
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/
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≤1PPM
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≤1PPM
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/
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Other amino acids
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individual impurities≤0.5% total impurities≤2.0%
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conform
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≤0.50%
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individual impurities≤0.20% total impurities≤0.5%
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Ninhydrin-positive substances
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/
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/
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/
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conform
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Loss on drying
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≤0.20%
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≤0.20%
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≤0.20%
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≤0.50%
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Residue on ignition
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≤0.10%
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≤0.10%
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≤0.10%
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≤0.10%
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Organic volatile impurities
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/
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/
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/
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/
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Endotoxin
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/
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<12EU/g
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/
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Function:
1.Serine is important in metabolism in that it participates in the biosynthesis of purines and pyrimidines. It is the precursor to several amino acids including glycine and cysteine, and tryptophan in bacteria. It is also the precursor to numerous other metabolites, including sphingolipids and folate, which is the principal donor of one-carbon fragments in biosynthesis.
2.Serine plays an important role in the catalytic function of many enzymes. It has been shown to occur in the active sites of chymotrypsin, trypsin, and many other enzymes. The so-called nerve gases and many substances used in insecticides have been shown to act by combining with a residue of serine in the active site of acetylcholine esterase, inhibiting the enzyme completely.
3.Serine sidechains are often hydrogen bonded; the commonest small motifs formed are ST turns, ST motifs (often at the beginning of alpha helices) and ST staples (usually at the middle of alpha helices).
As a constituent (residue) of proteins, its side chain can undergo O-linked glycosylation, which may be functionally related to[clarification needed] diabetes.
4.D-serine was thought to exist only in bacteria until relatively recently; it was the second D amino acid discovered to naturally exist in humans, present as a signalling molecule in the brain, soon after the discovery of D-aspartate. Had D amino acids been discovered in humans sooner, the glycine site on the NMDA receptor might instead be named the D-serine site. Apart from central nervous system, D-serine plays a signaling role in peripheral tissues and organs such as cartilage, kidney and corpus cavernosum.
5.L-Serine is sweet with minor umami and sour tastes at high concentration.Pure D-serine is an off-white crystalline powder with a very faint musty aroma. D-Serine is sweet with an additional minor sour taste at medium and high concentrations.
Application:
1. Used as biochemical reagent and food additive.
2. Nutrition supplement, as a skin nutrition additive in cosmetics.
3. It can be used for the research of biochemistry and nutrition, and can also be used as the raw material for the synthesis of cycloserine.
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